Does a paramedic student's exposure to cardiac cases during internship, clinical component, or simulation deepen understanding of cardiac conditions?
Abstract Objective To investigate the role of longitudinal plasma neurofilament heavy chain protein NfH levels as an indicator of clinical progression and survival in amyotrophic lateral sclerosis ALS.
Methods A cross-sectional study involving clinically heterogeneous patients with ALS and healthy and neurological controls was extended to include a prospective analysis of 74 of these ALS cases, with samplings at approximately 3-month intervals in a follow-up period of up to 3 years.
We analysed the correlation between longitudinal NfH-phosphoform levels and disease progression. Temporal patterns of NfH changes were evaluated using multilevel linear regression. Results Baseline plasma NfH levels were higher than controls only in patients with ALS with short disease duration to baseline sampling.
Compared with controls, fast-progressing patients with ALS, particularly those with a short diagnostic latency and disease duration, had higher plasma NfH levels at an early stage and lower levels closer to end-stage disease. Lower NfH levels between visits were associated with rapid functional deterioration.
Conclusions Disease progression in ALS involves defined trajectories of plasma NfH levels, reflecting speed of neurological decline and survival.
Intervisit plasma NfH changes are also indicative of disease progression. This study confirms that longitudinal measurements of NfH plasma levels are more informative than cross-sectional studies, where the time of sampling may represent a bias in the interpretation of the results.
Autoantibodies against NfH aggregates and NfH cleavage products may explain the variable expression of plasma NfH with disease progression.
Trail registration number Keywords: ALS, Motor Neuron Disease, Neuroimmunology Introduction Amyotrophic lateral sclerosis ALS is a relentless and mostly fatal neuromuscular disorder where the main pathological end point is the loss of motor cells.
They are among the main by-products of axonal loss and their phosphoforms accumulate in the perikaryon and in axonal spheroids. Longitudinal studies of Nf expression at multiple time points, together with the rate of neurological decline may be a more appropriate approach to assess the bioavailability of Nfs in relationship to the natural development of the disease and eventually to treatment response.
In this study, we have up graded the sensitivity of a plasma NfH assay to obtain reliable longitudinal measurements in a large and heterogeneous ALS cohort and evaluate whether this marker could be informative of defined patterns of disease progression.
We have tested plasma NfH levels over multiple time points in a follow-up period of up to 3 years in a subset of patients with ALS, using a multilevel analysis of temporal changes of this analyte in relationship to defined clinimetrics.
Patients with ALS are stratified into distinct NfH temporal profiles which reflect disease progression and duration. In most cases, patients with ALS consented for the study shortly after diagnosis, although recruitment was not limited to newly diagnosed cases.
Exclusion criteria included neurological comorbidities likely to affect Nf homeostasis, including previous neurosurgical operations, peripheral neuropathies and a recent history of neurotrauma.Nov 18, · ALS Forum» ALS Topics» ALS Research & Treatments» Peony root and paeoniflorin (long essay) Forum Jump ALS Topics - ALS Research & Treatments - Living with ALS - ALS Advocacy - Military Service and ALS - Forum’s Choice Program at ALS TDI - Philosophy and Feedback - Irrelevant to ALS.
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PUBLIC ABSTRACT Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that attacks the motor neurons of the brain and spinal cord of healthy adults.
Disease Research Paper: Lou Gehrig’s Disease / ALS (Amyotrophic Lateral Sclerosis) ALS (Amyotrophic Lateral Sclerosis) or Lou Gehrig’s Disease is a classified as a degenerative neurological disorder that inhibits motor neurons in the spinal cord and brain to function properly. Research paper.
Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study.
Amyotrophic lateral sclerosis (ALS) is a relentless and mostly fatal neuromuscular disorder where the main pathological end point is the loss of motor cells. 1 Typically.
ALS research needs to become more prevalent and publicized by educating people about what ALS is, the three types of ALS and some of famous cases of ALS. /5(2).